Both eszopiclone and sustained-release zolpidem are effective for both sleep-onset and sleep-maintenance insomnia, with a reduced abuse potential and long-term. Zolpidem extended-release, or controlled-release (CR), is a new formulation of zolpidem, a nonbenzodiazepine hypnotic. It is indicated in the US for the. Is not subject to the Controlled Substances Act. 1, Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. Triazolam (Halcion). Other sedatives. Nonbenzodiazepine “Z-drugs” sedative-hypnotics are drugs that differ in structure from benzodiazepines. Learn about sleep disorder drugs (hypnotics/sedatives) side effects and their uses Tegretol (carbamazepine); Carbatrol (carbamazepine extended-release). Sedatives, or central nervous system depressants, are a group of drugs that slow brain activity. People use these drugs to help them calm. Zolpidem is now available in an extended release version, Ambien CR. These older medications also tend to have a sedative effect or make. Eszopiclone, lemborexant, suvorexant, and zolpidem controlled-release are the only prescription nonbenzodiazepine drugs shown to improve. Guanfacine extended release (GXR) is a non-stimulant medication used for the treatment of ADHD in children (aged 6–12 years) and adolescents (aged 13–17 years). Ambien CR® (zolpidem extended-release tablets) Sedative hypnotic medications are medically necessary when the following are met.